Issue 16, 2020

Regio- and stereoselective C(sp2)–H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis

Abstract

A straightforward and efficient C(sp2)–H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis is demonstrated. The transformation proceeded smoothly without resorting to expensive and potentially toxic iridium or ruthenium polypyridyl-based photocatalysts under mild conditions, furnishing a diverse range of synthetically crucial, geometrically defined β-acylated enamides in a stereoselective and regioselective manner.

Graphical abstract: Regio- and stereoselective C(sp2)–H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis

Supplementary files

Article information

Article type
Paper
Submitted
08 Jun 2020
Accepted
20 Jul 2020
First published
21 Jul 2020

Green Chem., 2020,22, 5497-5503

Regio- and stereoselective C(sp2)–H acylation of enamides with aldehydes via transition-metal-free photoredox catalysis

K. Zhao, X. Zhang, J. Tao, X. Wu, J. Wu, W. Li, T. Zhu and T. Loh, Green Chem., 2020, 22, 5497 DOI: 10.1039/D0GC01947J

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