Janus nanozyme–drug nanosystems for synergistic anti-inflammatory treatment of nasal polyps

Abstract

A nasal polyp is a chronic inflammation that still has a tendency to recur after medical and surgical treatments, and greatly decreases the quality of life. Since the efficacy of current therapeutic methods is limited, it is urgent to develop a novel strategy to realize multi-modal anti-inflammatory treatment. In this study, multifunctional Au–CeO₂ JNPs capable of eliminating reactive oxygen species (ROS), loading anti-inflammatory drugs (Danshensu sodium salt), and being detected by X-ray computed tomography (CT) were developed for imaging guided synergistic anti-inflammatory treatment of nasal polyps. As expected, the Au–CeO₂ JNPs showed excellent CT imaging performance, and the levels of ROS and pro-inflammatory cytokines decreased after the primary human nasal polyp epithelial cell (HNEC) treatment with Au–CeO₂ JNPs, indicating the synergistic ROS elimination effect between Au and CeO₂ domains. Furthermore, compared with individual CeO₂ NPs and Au–CeO₂ JNPs, the Danshensu sodium salt (DSS) loaded Au–CeO₂ JNPs showed stronger anti-inflammatory performance due to the synergistic pharmacotherapy and enzymatic action. Therefore, this novel nanozyme–drug nanosystem provided a new concept and approach in the progress of anti-inflammation.