Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

Taehyung Kim; Ha Na Hyun; Roun Heo; Keonwook Nam; Kyungjik Yang; Young Min Kim; Yoon Suk Lee; Jae Yoon An; Jae Hyung Park; Ki Young Choi; Young Hoon Roh

doi:10.1039/D0CC01848A

Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells†

Taehyung Kim,‡^a Ha Na Hyun,‡^a Roun Heo,‡^b Keonwook Nam,^a Kyungjik Yang,^a Young Min Kim,^a Yoon Suk Lee,^a Jae Yoon An,^c Jae Hyung Park,

^bc Ki Young Choi

*^d and Young Hoon Roh

*^a

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* Corresponding authors

^a Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
E-mail: yr36@yonsei.ac.kr

^b Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Republic of Korea

^c School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Republic of Korea

^d Natural Product Informatics Research Center, Korea Institute of Science and Technology, 679 Saimdang-ro, Gangneung-si, Gangwon-do, Republic of Korea
E-mail: kiyoungchoi@kist.re.kr

Abstract

A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.

Chemical Communications

Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells†

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Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

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