Issue 9, 2020

Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

Abstract

Silver (Ag(I)) binding to consensus zinc fingers (ZFs) causes Zn(II) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(I)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.

Graphical abstract: Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

Supplementary files

Article information

Article type
Communication
Submitted
04 Dec 2019
Accepted
19 Dec 2019
First published
08 Jan 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 1329-1332

Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

K. Kluska, M. D. Peris-Díaz, D. Płonka, A. Moysa, M. Dadlez, A. Deniaud, W. Bal and A. Krężel, Chem. Commun., 2020, 56, 1329 DOI: 10.1039/C9CC09418K

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