Issue 20, 2020

Novel D–π-A type near-infrared fluorescent probes for the detection of Aβ40 aggregates

Abstract

Aberrant accumulation of Amyloid-β (Aβ) peptide is closely related to Alzheimer's disease. Thus, it is important to develop featured probes for the specific detection of Aβ species. Herein, we designed and synthesized a novel near-infrared fluorescent probe SDPY based on the D–π-A architecture for the detection of Aβ aggregates. The probe SDPY displayed higher affinity for Aβ40 aggregates over Aβ42 aggregates in solution (Kd = 164 nM vs. 2.1 μM). In addition, SDPY showed excellent anti-interference against a wide range of other substances. Furthermore, SDPY was capable of labeling Aβ40 aggregates better than Aβ42 aggregates in the brain sections of AD transgenic mouse models.

Graphical abstract: Novel D–π-A type near-infrared fluorescent probes for the detection of Aβ40 aggregates

Supplementary files

Article information

Article type
Paper
Submitted
12 Jun 2020
Accepted
18 Jul 2020
First published
21 Jul 2020

Analyst, 2020,145, 6579-6585

Novel D–π-A type near-infrared fluorescent probes for the detection of Aβ40 aggregates

G. Lv, Y. Xu, J. Yang, W. Li, C. Li and A. Sun, Analyst, 2020, 145, 6579 DOI: 10.1039/D0AN01180K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements