Issue 60, 2019

Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position

Abstract

An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation.

Graphical abstract: Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position

Supplementary files

Article information

Article type
Paper
Submitted
25 Sep 2019
Accepted
15 Oct 2019
First published
30 Oct 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 35098-35101

Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position

J. Xie, Z. Wang and G. Jiang, RSC Adv., 2019, 9, 35098 DOI: 10.1039/C9RA07785E

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