Issue 54, 2019

Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides

Abstract

This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C–N bonds. In this reaction, molecular iodine was used as the catalyst and t-butyl hydroperoxide was used as the oxidant.

Graphical abstract: Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides

Supplementary files

Article information

Article type
Paper
Submitted
12 Sep 2019
Accepted
25 Sep 2019
First published
02 Oct 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 31212-31216

Iodine-catalyzed sulfonylation of sulfonyl hydrazides with tert-amines: a green and efficient protocol for the synthesis of sulfonamides

J. Chen, X. Han, L. Mei, J. Liu, K. Du, T. Cao and Q. Li, RSC Adv., 2019, 9, 31212 DOI: 10.1039/C9RA07361B

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