Issue 59, 2019

Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity

Abstract

Twelve undescribed sesquiterpenoids, fomitopins A–L (1–12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1–12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

Graphical abstract: Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity

Supplementary files

Article information

Article type
Paper
Submitted
30 Jul 2019
Accepted
12 Sep 2019
First published
23 Oct 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 34184-34195

Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity

S. Tai, P. Kuo, C. Hung, Y. Lin, T. Hwang, S. H. Lam, D. Kuo, J. Wu, H. Hung and T. Wu, RSC Adv., 2019, 9, 34184 DOI: 10.1039/C9RA05899K

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