Issue 29, 2019
From the journal:

RSC Advances

Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia†

Yui Umehara,a   Toki Kageyama,a   Aoi Son,a   Yu Kimura,a   Teruyuki Kondo ORCID logo *a  and  Kazuhito Tanabe ORCID logo *b  

* Corresponding authors

a Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, Japan
E-mail: teruyuki@scl.kyoto-u.ac.jp
Fax: +81-75-383-2504
Tel: +81-75-383-7055

b Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Japan
E-mail: tanabe.kazuhito@chem.aoyama.ac.jp
Fax: +81-42-759-6493
Tel: +81-42-759-6229

Abstract

Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging. We prepared GNRs with hypoxia-targeting nitroimidazole units (G-NI) on their surface. Biological experiments revealed that G-NI produced a strong photoacoustic signal in hypoxic tumor cells and tissues.

Graphical abstract: Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

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Article information

DOI
https://doi.org/10.1039/C9RA00951E
Article type
Paper
Submitted
05 Feb 2019
Accepted
15 May 2019
First published
29 May 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 16863-16868

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Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

Y. Umehara, T. Kageyama, A. Son, Y. Kimura, T. Kondo and K. Tanabe, RSC Adv., 2019, 9, 16863 DOI: 10.1039/C9RA00951E

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