Issue 12, 2019, Issue in Progress

Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

Abstract

A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO in vivo.

Graphical abstract: Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

Supplementary files

Article information

Article type
Paper
Submitted
06 Dec 2018
Accepted
15 Feb 2019
First published
25 Feb 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 6510-6514

Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

Y. Ma, H. Tian, Z. Jin, X. Li and Y. Li, RSC Adv., 2019, 9, 6510 DOI: 10.1039/C8RA10053E

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