Nickel-promoted C(2)–H amidation of quinoline N-oxides with N-fluorobenzenesulfonimide

Abstract

Reported herein is an unprecedented nickel-promoted C–H amidation reaction of quinoline N-oxides using N-fluorobenzenesulfonimide (NFSI) as the amination reagent. This strategy provides a convenient access to a variety of useful 1,2-dihydro-2-iminoquinolines in moderate to good yields. Notable advantages of this protocol include easy operation and mild reaction conditions.