Aminophosphonates and aminophosphonic acids with tetrasubstituted stereogenic center: diastereoselective synthesis from cyclic ketimines†
Jakub
Iwanejko, 
a
Anna
Brol,
a
Bartłomiej M.
Szyja,
b
Marek
Daszkiewicz,
c
Elżbieta
Wojaczyńska
*a
and
Tomasz K.
Olszewski
*a
a
Anna
Brol,
a
Bartłomiej M.
Szyja,
b
Marek
Daszkiewicz,
c
Elżbieta
Wojaczyńska
*a
and
Tomasz K.
Olszewski
*a
Abstract
New chiral tetrasubstituted aminophosphonic acid derivatives of hexahydroquinoxalin-2(1H)-one were synthesised via highly diastereoselective hydrophosphonylation of the corresponding imines with tris(trimethylsilyl) phosphite as phosphorus nucleophile. High asymmetric induction, good yields, mild reaction conditions, and ease of purification of the final products are the key advantages of the presented protocol.
- This article is part of the themed collection: Synthetic methodology in OBC
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