A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(II) complex

Alfonso Annunziata; Maria Elena Cucciolito; Roberto Esposito; Paola Imbimbo; Ganna Petruk; Giarita Ferraro; Valerio Pinto; Angela Tuzi; Daria Maria Monti; Antonello Merlino; Francesco Ruffo

doi:10.1039/C9DT01614G

A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex†

Alfonso Annunziata,

^ab Maria Elena Cucciolito,

^ab Roberto Esposito,

^ab Paola Imbimbo,

^a Ganna Petruk,

^a Giarita Ferraro,

^a Valerio Pinto,^a Angela Tuzi,

^a Daria Maria Monti,

*^a Antonello Merlino

*^a and Francesco Ruffo

*^ab

Author affiliations

* Corresponding authors

^a Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cintia 21, I-80126 Napoli, Italy
E-mail: mdmonti@unina.it, antonello.merlino@unina.it, ruffo@unina.it

^b Consorzio Interuniversitario di Reattività Chimica e Catalisi, via Celso Ulpiani 27, I-70126 Bari, Italy

Abstract

New five-coordinate Pt(II) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.

Dalton Transactions

A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex†

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A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(II) complex

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