Issue 82, 2019
From the journal:

Chemical Communications

A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery†

Shatadru Chakravarty, ORCID logo abc   Saurav J. Sarma, ORCID logo ade   Lalit N. Goswami, ORCID logo a   Quan-Yu Cai,af   Erik M. Shapiro,bc   M. Frederick Hawthornea  and  Lixin Ma ORCID logo *af  

* Corresponding authors

a International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, MO, USA
E-mail: mal@health.missouri.edu

b Molecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, MI, USA

c Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA

d Bond Life Sciences Centre, University of Missouri, Columbia, MO 65201, USA

e MU Metabolomics Centre, University of Missouri, Columbia, MO, USA

f Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA

Abstract

A multimeric MRI contrast agent based on the closo-borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo-borane motif using Cu(I) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro/in vivo.

Graphical abstract: A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery

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Article information

DOI
https://doi.org/10.1039/C9CC05383B
Article type
Communication
Submitted
12 Jul 2019
Accepted
16 Sep 2019
First published
27 Sep 2019

Chem. Commun., 2019,55, 12348-12351

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A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery

S. Chakravarty, S. J. Sarma, L. N. Goswami, Q. Cai, E. M. Shapiro, M. F. Hawthorne and L. Ma, Chem. Commun., 2019, 55, 12348 DOI: 10.1039/C9CC05383B

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