Beacon-mediated Exponential Amplification Reaction (BEAR) enables isothermal, exponential signal amplification. BEAR uses only a single enzyme and a single primer. Detection of 0.2 amol of a mitochondrial DNA with a point mutation in less than an hour demonstrates an application of the BEAR technique for nucleic acid research.
A. M. Newbigging, H. Zhang and X. C. Le, Chem. Commun., 2019, 55, 10677 DOI: 10.1039/C9CC04226A
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