Issue 30, 2019

Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance

Abstract

Amphiphilic molecules linked by an aromatic nucleus were developed that showed high selectivity toward bacteria over mammalian cells, and low drug resistance. A promising compound 4g exhibited strong bactericidal activity against a panel of sensitive and resistant bacteria, low toxicity, the ability to reduce cell viability in biofilms, stability in mammalian fluids, rapid killing of pathogens, and high in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA).

Graphical abstract: Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance

Supplementary files

Article information

Article type
Communication
Submitted
30 Jan 2019
Accepted
13 Feb 2019
First published
15 Feb 2019

Chem. Commun., 2019,55, 4307-4310

Low-toxicity amphiphilic molecules linked by an aromatic nucleus show broad-spectrum antibacterial activity and low drug resistance

W. Chu, Y. Yang, S. Qin, J. Cai, M. Bai, H. Kong and E. Zhang, Chem. Commun., 2019, 55, 4307 DOI: 10.1039/C9CC00857H

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