Sheet-like and tubular aggregates of protein nanofibril–phosphate hybrids

Abstract

Bovine serum albumin assembled into supramolecular fibrils and aligned into microtubes and nanosheets upon simply heating and cooling its solution in phosphate buffer under carefully-selected conditions. This unique “one-batch” synthesis was justified by the one-dimensional growth of phosphate crystals in combination with the strong affinity of phosphate ions to protein fibrils.