Issue 41, 2019
From the journal:

Analytical Methods

A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection†

Duo Lin, ORCID logo a   Jiahui Zhou,a   Yun Yu,a   Weiwei Chen,a   Pei-Hsuan Liao,b   Hao Huang*a  and  Kien Voon Kong ORCID logo *b  

* Corresponding authors

a College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China
E-mail: fjtcm@126.com

b Department of Chemistry, National Taiwan University, Taipei, Taiwan
E-mail: kvkong@ntu.edu.tw

Abstract

A fast SERS and colorimetric dual-modal assay for thiol detection was developed using an unsaturated triosmium carbonyl cluster, Os3(CO)10(μ-H)2, as a detection probe. The cluster undergoes a distinct color change in the presence of thiol and the SERS spectrum shows a shift in the CO stretching vibration, located in a silent region where there is no interference from biomolecules. Such assay offers high sensitivity with a detection limit up to 0.1 μM by SERS.

Graphical abstract: A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C9AY01466G
Article type
Communication
Submitted
09 Jul 2019
Accepted
01 Oct 2019
First published
03 Oct 2019

Anal. Methods, 2019,11, 5232-5236

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A dual-mode biosensor combining transition metal carbonyl-based SERS and a colorimetric readout for thiol detection

D. Lin, J. Zhou, Y. Yu, W. Chen, P. Liao, H. Huang and K. V. Kong, Anal. Methods, 2019, 11, 5232 DOI: 10.1039/C9AY01466G

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