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Bioactive Nano Metal-Organic Frameworks as Antimicrobials Against Gram-Positive and Gram-Negative Bacteria

Abstract

More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacy of three Zn-based nano metal-organic frameworks (nMOFs) – IRMOF-3, MOF-5, and Zn-BTC – were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli, Staphylococcus aureus, Staphylococcus lentus, and Listeria monocytogenes, the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-based nMOFs can reduce the burden on new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics.

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Publication details

The article was received on 23 Mar 2018, accepted on 10 May 2018 and first published on 11 May 2018


Article type: Paper
DOI: 10.1039/C8TX00087E
Citation: Toxicol. Res., 2018, Accepted Manuscript
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    Bioactive Nano Metal-Organic Frameworks as Antimicrobials Against Gram-Positive and Gram-Negative Bacteria

    N. Bhardwaj, S. K. Pandey, J. Mehta, S. Kumar, K. Kim and A. Deep, Toxicol. Res., 2018, Accepted Manuscript , DOI: 10.1039/C8TX00087E

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