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Developmental toxicity, bioaccumulation and distribution of oxidized single walled carbon nanotubes in Artemia salina

Abstract

With the increasing productions and applications of single walled carbon nanotubes (SWCNTs), concerns about the likelihood of SWCNTs presenting in the aquatic environment and the subsequent effects on aquatic organisms are emerging. This work aimed to investigate the developmental toxicity, bioaccumulation and distribution of oxidized SWCNTs (O-SWCNTs) in a marine model organism, Artemia salina (A. salina). Results indicated that hatching rates of capsulated and decapsulated cysts were decreased with the O-SWCNTs concentrations increased from 0 to 600 mg/L at 12, 18, 24 and 36 h. For instar I, II and III larvae exposure to 600 mg/L, the mean mortality rates were 36.1%, 57.9% and 45.2%, respectively. Both body length and swimming speed showed concentration–dependent decrease after exposure to O-SWCNTs for 24 h. Inhibition of swimming may be caused by 1) malformation of gills; 2) attachment of O-SWCNTs on the gills. Reactive oxygen species (ROS) and antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) activities were substantially increased following exposure, indicating that toxic effects were related to oxidative stress. O-SWCNTs can be ingested, accumulated and excreted by A. salina, and distributed in intestine, lipid vesicle and phagocyte. However, the accumulated O-SWCNTs were not completely excreted by A. salina. Uptake kinetics data showed that O-SWCNTs contents were increased from 1 to 48 h followed by decreased from 48 to 72 h with a range from 0.08 to 5.7 mg/g. The combined results so far indicate that O-SWCNTs have the potential to affect aquatic organisms when released into the marine ecosystems.

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Publication details

The article was received on 19 Mar 2018, accepted on 27 Apr 2018 and first published on 03 May 2018


Article type: Paper
DOI: 10.1039/C8TX00084K
Citation: Toxicol. Res., 2018, Accepted Manuscript
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    Developmental toxicity, bioaccumulation and distribution of oxidized single walled carbon nanotubes in Artemia salina

    B. Zhu, S. Zhu, J. Li, X. Hui and G. Wang, Toxicol. Res., 2018, Accepted Manuscript , DOI: 10.1039/C8TX00084K

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