Jump to main content
Jump to site search

Issue 2, 2018
Previous Article Next Article

Assessing the antiandrogenic properties of propyl paraben using the Hershberger bioassay

Author affiliations

Abstract

Propyl paraben is a widely used preservative in pharmaceuticals, cosmetics, and foods preventing microbial and fungal contamination. This study was designed to investigate antiandrogenic profiles of propyl paraben following oral doses at 10, 250, and 750 mg kg−1 day to immature male rats using the Hershberger Bioassay. Rats were divided into six groups including solvent control, negative control (0.4 mg kg−1 day testosterone propionate = TP), positive control (3 mg kg−1 day flutamide = FLU) and treatment groups (10, 250, and 750 mg kg−1 day testosterone propionate + Propyl paraben). Propyl paraben (PP) significantly decreased all accessory sex organ weights at each dose of 250 and 750 mg kg−1 day compared to control groups. Thus, we found that propyl paraben had antiandrogenic activity within the supported results of increasing LH levels and histopathologic results such atrophy, hyalinization, and anastomosis on androgenic tissues.

Graphical abstract: Assessing the antiandrogenic properties of propyl paraben using the Hershberger bioassay

Back to tab navigation

Publication details

The article was received on 30 Nov 2017, accepted on 16 Jan 2018 and first published on 25 Jan 2018


Article type: Paper
DOI: 10.1039/C7TX00319F
Citation: Toxicol. Res., 2018,7, 235-243
  •   Request permissions

    Assessing the antiandrogenic properties of propyl paraben using the Hershberger bioassay

    E. Özdemir, N. Barlas and M. A. Çetinkaya, Toxicol. Res., 2018, 7, 235
    DOI: 10.1039/C7TX00319F

Search articles by author

Spotlight

Advertisements