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Chromatin dynamics underlying latent responses to xenobiotics

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Abstract

Pleiotropic xenobiotics can trigger dynamic alterations in mammalian chromatin structure and function but many of these are likely non-adverse and simply reflect short-term changes in DNA transactions underlying normal homeostatic, adaptive and protective cellular responses. However, it is plausible that a subset of xenobiotic-induced perturbations of somatic tissue or germline epigenomes result in delayed-onset and long-lasting adverse effects, in particular if they occur during critical stages of growth and development. These could include reprogramming, dedifferentiation, uncontrolled growth, and cumulative toxicity effects through molecular memory of prior xenobiotic exposures or altered susceptibility to subsequent xenobiotic exposures. Here we discuss the current evidence for epigenetic mechanisms underlying latent responses to xenobiotics, and the potential for identifying molecular epigenetic changes that are prodromal to overt morphologic or functional toxicity phenotypes.

Graphical abstract: Chromatin dynamics underlying latent responses to xenobiotics

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Publication details

The article was received on 28 Nov 2017, accepted on 26 Feb 2018 and first published on 28 Feb 2018


Article type: Review Article
DOI: 10.1039/C7TX00317J
Citation: Toxicol. Res., 2018, Advance Article
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    Chromatin dynamics underlying latent responses to xenobiotics

    J. Moggs and R. Terranova, Toxicol. Res., 2018, Advance Article , DOI: 10.1039/C7TX00317J

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