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Bixin Protects against Particle-induced Long-term Lung Injury in an NRF2-dependent Manner


Scope: Particles-induced lung injury is a kind of comprehensive pulmonary disease with not only inflammation but also fibrosis. Bixin is a natural compound that is widely used as food addictive. Our previous studies demonstrated that bixin could alleviate inflammation in ventilation-induced acute lung injury as well as UV-exposure caused skin damage. But whether it could depress silica-induced long-term comprehensive lung injury and the mechanism of bixin in this protection has not yet been studied. Methods: A murine SiO2-induced long-term comprehensive lung injury model was established through silica intratracheal instillation. To elucidate the effects and mechanisms of bixin in silica-induced pulmonary inflammation and fibrosis, we treated the mice with bixin following silica instillation. Results: Bixin treatment attenuated the accumulation of inflammatory cells which significantly ameliorated pathological inflammation and fibrotic development in the lung. In addition, Intraperitoneal (i.p.) injection of bixin in mice led to upregulation of NRF2 response in the lung. Since alveolar macrophage activation plays a vital role in the initiation and progression of this injury, the mechanism was further studied in the THP-1 macrophagy cells. Bixin activated NRF2 signals via blocking KEAP1 mediated ubiquitylation and degradation of NRF2. Conclusions: Our work has brought insights into exploring anti-particles-induced lung injury activities in daily consumption of natural products. In addition, our study also inspires the discovery of new beneficial effects of bixin and its application in the treatment of other inflammatory disease.

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Publication details

The article was received on 12 Nov 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018

Article type: Paper
DOI: 10.1039/C7TX00304H
Citation: Toxicol. Res., 2018, Accepted Manuscript
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    Bixin Protects against Particle-induced Long-term Lung Injury in an NRF2-dependent Manner

    L. Xue, H. Zhang, J. Zhang, B. Li, Z. Zhang and S. Tao, Toxicol. Res., 2018, Accepted Manuscript , DOI: 10.1039/C7TX00304H

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