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Issue 4, 2018
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The failure of rodent carcinogenesis as a model for Man

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Abstract

Recent advances in our understanding of the process of carcinogenesis in Man have required revision of our thinking about the classical initiation/promotion sequence; understanding must now encompass the roles of both genetic and epigenetic change, realisation of the importance of the variable genetic backgrounds of the tumour bearers in any group and an understanding of the importance of random genetic events over time. The behavior of tumours, once established, is more complex than has been thought. Current views of the processes involved are not modelled in toxicity testing programmes.

Graphical abstract: The failure of rodent carcinogenesis as a model for Man

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Publication details

The article was received on 23 Oct 2017, accepted on 14 Dec 2017 and first published on 20 Dec 2017


Article type: Review Article
DOI: 10.1039/C7TX00283A
Citation: Toxicol. Res., 2018,7, 553-557
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    The failure of rodent carcinogenesis as a model for Man

    C. Berry, Toxicol. Res., 2018, 7, 553
    DOI: 10.1039/C7TX00283A

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