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Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

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Abstract

Sensitisation of the respiratory tract to chemicals resulting in respiratory allergy and allergic asthma is an important occupational health problem, and presents toxicologists with no shortage of challenges. A major issue is that there are no validated or, even widely recognised, methods available for the identification and characterisation of chemical respiratory allergens, or for distinguishing respiratory allergens from contact allergens. The first objective here has been review what is known (and what is not known) of the mechanisms through which chemicals induce sensitisation of the respiratory tract, and to use this information to construct a hybrid Adverse Outcome Pathway (AOP) that combines consideration of both skin and respiratory sensitisation. The intention then has been to use the construction of this hybrid AOP to identify areas of commonality/confluence, and areas of departure/divergence, between skin sensitisation and sensitisation of the respiratory tract. The hybrid AOP not only provides a mechanistic understanding of how the processes of skin and respiratory sensitisation differ, buy also a means of identifying areas of uncertainty about chemical respiratory allergy that benefit from a further investment in research.

Graphical abstract: Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

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Publication details

The article was received on 12 Oct 2017, accepted on 18 Jan 2018 and first published on 26 Jan 2018


Article type: Review Article
DOI: 10.1039/C7TX00272F
Citation: Toxicol. Res., 2018, Advance Article
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    Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

    I. Kimber, A. Poole and D. A. Basketter, Toxicol. Res., 2018, Advance Article , DOI: 10.1039/C7TX00272F

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