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Using porous magnetic iron oxide nanomaterials as a facile photoporation nanoplatform for macromolecular delivery

Abstract

The intracellular delivery of exogenous macromolecules such as functional proteins, antibodies, polysaccharides and nucleic acids into living cells for biomedical applications is of great interest. Even though great efforts have been devoted to the task, universal delivery systems that provide excellent intracellular delivery performance combined with easy cell recovery are urgently needed. Magnetic iron oxide nanoparticles show promising potential for various biomedical applications because of their advantages of high biocompatibility and cost-effectiveness. Herein, a new facile platform for macromolecular delivery was developed based on the photothermal properties of porous magnetic iron oxide nanoparticles (P-MNPs). The near-infrared radiation (NIR) absorption behavior of P-MNPs remarkably facilitates the delivery of macromolecules into cells while maintaining high cell viability. Furthermore, the assistance of polycationic polyethylenimine improves the efficiency of DNA delivery. Most importantly, the cells could be easily recovered after macromolecular delivery by trypsinization, which is of great significance for the further practical application of the delivery system. The facile and cost-effective platform proposed in this work provides a new avenue for the utilization of P-MNPs in macromolecular delivery.

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Publication details

The article was received on 19 Apr 2018, accepted on 14 Jun 2018 and first published on 14 Jun 2018


Article type: Paper
DOI: 10.1039/C8TB01026A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Using porous magnetic iron oxide nanomaterials as a facile photoporation nanoplatform for macromolecular delivery

    L. Wang, J. Wu, C. Hu, Y. Hu, Y. Pan, Q. Yu and H. Chen, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB01026A

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