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Issue 28, 2018
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A single-interface photoelectrochemical sensor based on branched TiO2 nanorods@strontium titanate for the detection of two biomarkers

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Abstract

In this study, a single-interface photoelectrochemical (PEC) sensor for detecting two antigens, alpha fetoprotein (AFP) and cancer antigen 153 (CA 153), was achieved based on the heterostructure of branched titanium dioxide nanorods (B-TiO2 NRs)@strontium titanate (SrTiO3) heterostructures. The B-TiO2 NRs@SrTiO3 heterostructure, prepared by a facile hydrothermal method with the feature of enhanced photogenerated charge carrier separation properties, was first employed as a photoactive substrate for anchored analyst. In order to achieve the goal of successfully detecting two biomarkers at a single interface, the two specific enzyme tags β-galactosidase and acetylcholine esterase linked with a secondary detection antibody were utilized to catalytically hydrolyze p-aminophenyl galactopyranoside and acetylthiocholine to p-aminophenol and thiocholine, respectively. Based on the above enzyme-catalyzed reactions to produce sacrificial electron donors, the photocurrent signals generated from different analytes could be distinguished at a single interface. The results demonstrate that this single-interface PEC sensor not only provides a method for the early detection of AFP and CA 153 but also provides new insight into designing a novel PEC sensor for the detection of two biomarkers with high efficiency and a simple method of operation.

Graphical abstract: A single-interface photoelectrochemical sensor based on branched TiO2 nanorods@strontium titanate for the detection of two biomarkers

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Publication details

The article was received on 16 Apr 2018, accepted on 11 Jun 2018 and first published on 14 Jun 2018


Article type: Paper
DOI: 10.1039/C8TB00992A
Citation: J. Mater. Chem. B, 2018,6, 4697-4703
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    A single-interface photoelectrochemical sensor based on branched TiO2 nanorods@strontium titanate for the detection of two biomarkers

    J. Xue, C. Gao, L. Zhang, K. Cui, W. He and J. Yu, J. Mater. Chem. B, 2018, 6, 4697
    DOI: 10.1039/C8TB00992A

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