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A single-interface photoelectrochemical sensor based on branched TiO2 nanorods@strontium titanate for two biomarkers detection

Abstract

In this study, a single-interface photoelectrochemical (PEC) sensor for detecting two antigens of alpha fetoprotein (AFP) and cancer antigen 153 (CA 153) was achieved on the basis of branched titanium dioxide nanorods (B-TiO2 NRs)@strontium titanate (SrTiO3) heterostructure. The B-TiO2 NRs@SrTiO3 heterostructure, prepared by a facile hydrothermal method with the feature of enhanced photogenerated charge carriers separation property, was firstly employed as photoactive substrate for analyst anchored. In order to achieving the goal of successfully detecting two biomarkers in single interface, the two specific enzyme tags of β-galactosidase and acetylcholine esterase linked with the secondary detection antibody are utilized to catalytic hydrolysis of p-aminophenyl galactopyranoside and acetylthiocholine to p-aminophenol and thiocholine, respectively. Based on the above enzyme-catalyzed reactions to produce sacrificial electron donators, the photocurrent signals generated from different analytes could be distinguished in single interface. The results demonstrated that this single-interface PEC sensor not only provides a mean for early detection of AFP and CA 153 but also shows new insights to design novel PEC sensor for two biomarkers detection with high efficiency and simple operation.

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Publication details

The article was received on 16 Apr 2018, accepted on 11 Jun 2018 and first published on 14 Jun 2018


Article type: Paper
DOI: 10.1039/C8TB00992A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    A single-interface photoelectrochemical sensor based on branched TiO2 nanorods@strontium titanate for two biomarkers detection

    J. Xue, C. Gao, L. Zhang, K. Cui, W. He and J. Yu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00992A

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