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Substrate-independent ultrathin hydrogel film as antifouling and antibacterial layer for microfiltration membrane anchored via layer-by-layer thiol-ene “click” reaction

Abstract

A substrate-independent ultrathin hydrogel film was constructed on microfiltration membrane through layer-by-layer (LbL) thiol-ene “click” chemistry to improve the antifouling and antibacterial properties. In our strategy, ene-functionalized dopamine was synthesized and coated onto a model substrate (polyethersulfone membrane) to introduce double bonds as anchoring sites of the hydrogel film; thiol-functionalized poly[oligo(ethylene glycol)mercaptosuccinate] (POEGMS) and ene-functionalized P(SBMA-co-AA) were synthesized as hydrogel precursors, respectively. Then, the membrane was alternately immersed into the precursor solutions to form ultrathin hydrogel film. Finally, Ag nanoparticles (AgNPs) were loaded into the hydrogel layer by adsorbing and reducing procedures. By coating the hydrogel films, the loaded AgNPs could kill almost all the contacted bacteria and the bacteria in the surrounding, and the enhanced hydrophilicity of the modified membrane could effectively prevent from the attachment of the bacteria. Meanwhile, the membrane flux showed no significantly decrease, the rejection ratio of BSA increased from 51% to 89%, and the FRR increased from 36% to 90%. Moreover, the improvement of hemocompatibility was confirmed by the declined plasma protein adsorption, prolonged clotting times, low hemolysis ratio, and prevented platelet adhesion. Compared with other techniques of attaching hydrogel films, the main advantage of the current technique was that the hydrogel film thickness could be well controlled within nanometer range, so it could significantly improve the antifouling and antibacterial properties of the membrane, but without compromising its permeability. Another advantage was that it was versatile for various substrate, such as PVDF, PAN, and CA. Therefore, the work opens up a facile and versatile route to anchor ultrathin hydrogel film onto polymeric membranes to achieve excellent antifouling, antibacterial and hemocompatible properties.

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Publication details

The article was received on 08 Apr 2018, accepted on 11 May 2018 and first published on 14 May 2018


Article type: Paper
DOI: 10.1039/C8TB00937F
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Substrate-independent ultrathin hydrogel film as antifouling and antibacterial layer for microfiltration membrane anchored via layer-by-layer thiol-ene “click” reaction

    M. He, Q. Wang, W. Zhao and C. Zhao, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00937F

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