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Osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold in the treatment of large bone defects

Abstract

Bone grafting remains the method of choice for the majority of surgeons in the treatment of large bone defects, since it fills spaces and provides support to enhance biological bone repair. Recently, we reported our research on a bioactive multiphase macroporous scaffold with interconnected porous structure, nano-crystal surface microstructure that can release bioactive ions. Moreover, we demonstrated the excellent in vitro biological activity of the scaffold. With this study, we set out to evaluate the in vivo, osteogenesis and vascularization of the scaffold in the treatment of large bone defects (10-mm radial bone defect in rabbits). In comparison with the control group, X-ray and Micro-CT results at the 4th and 8th week post-surgery the bioactive scaffold displayed an enhanced level of new bone and vessel formation. Histological results at the same weeks indicated improved bone formation, osseointegration and new vessel ingrowth inside the bioactive scaffold. These findings establish a good foundation for the potential clinical validation of the bioactive macroporous biomaterial scaffold for use as a bone substitute or in tissue engineering.

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Publication details

The article was received on 20 Mar 2018, accepted on 07 May 2018 and first published on 11 May 2018


Article type: Paper
DOI: 10.1039/C8TB00766G
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold in the treatment of large bone defects

    L. Chu, G. Jiang, X. Hu, T. D. James, X. He, Y. Li and T. Tang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00766G

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