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Controllable Synthesis of Fe3O4 Nanoflowers: Enhanced Imaging Guided Cancer Therapy and Comparison of Photothermal Efficiency with Black-TiO2

Abstract

Photothermal therapy (PTT) has emerged as one of the promising cancer therapy approaches. However, nanoparticles (NPs) which are used for PTT might be biopersistent and potentially toxic. The current research explores the promising use of Fe3O4 nanoflowers as a nontoxic, efficient photothermal, and strong T2 type of magnetic resonance imaging (MRI) contrast agent for imaging-guided photothermal cancer therapy. In this study, a facile solvothermal method is used to fabricate the PEG-coated Fe3O4 nanoflowers with controllable dimensions. The successful fabrication, effect of reaction parameters, and magnetic properties are deeply investigated. The therapeutic performance of Fe3O4 nanoflowers (Fe-NFs) is evaluated and compared with commercially available black TiO2 nanoparticles (b-TiO2) under 808 nm laser. The photothermal therapy efficiency of Fe-NFs is observed to be better than the reported Fe3O4 nanoparticles. In vitro and in vivo investigation demonstrates that the therapeutic performance of Fe-NFs is comparable to b-TiO2. Moreover, Fe-NFs show excellent magnetic properties and magnetic resonance imaging capability to monitor therapeutic performance.

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Publication details

The article was received on 19 Mar 2018, accepted on 14 May 2018 and first published on 15 May 2018


Article type: Paper
DOI: 10.1039/C8TB00745D
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Controllable Synthesis of Fe3O4 Nanoflowers: Enhanced Imaging Guided Cancer Therapy and Comparison of Photothermal Efficiency with Black-TiO2

    M. Saeed, M. Z. Iqbal, W. Ren, Y. Xia, C. Li, W. S. Khan and A. Wu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00745D

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