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Black Phosphorus analogue Tin Sulfide Nanosheets: Synthesis and Application as Near-Infrared Photothermal Agents and Drug Delivery Platforms for Cancer Therapy

Abstract

Two-dimensional (2D) inorganic nanomaterials for biomedical application still face the challenge of simultaneously offering a high photothermal conversion efficiency (PTCE), efficient drug delivery, biocompatibility and biodegradability. Herein, cancer treatment using a tin sulfide nanosheets (SnS NSs) based dual therapy nano-platform (SDTNP), including photothermal- and chemo-therapy, is demonstrated. SnS, a black phosphorus (BP) analogue binary IV–VI compound, was synthesized using liquid phase exfoliation. SnS NSs comprising 2–4 layers exhibited good biocompatibility and a high PTCE of 39.3 %, which is higher than other popular 2D materials. The SnS NSs showed a stable photothermal performance over 2 h of laser irradiation and exhibited ~14 % degradation after 10 h of irradiation. It was also found that SnS NSs show high loading of small molecules such as doxorubicin (DOX) (up to ~200 % in weight). Consequently, the SDTNP achieved notable tumor therapy through the combination of photothermal- and chemo-therapy both in vitro and in vivo. Our study may pave the way for the biomedical application of SnS and other IV−VI compound-based 2D nanomaterials. Compared with traditional therapies, SnS NSs based laser therapy is green and efficient, due to its biocompatibility, photo-degradability, high efficiency photothermal properties and high drug loading.

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Publication details

The article was received on 17 Mar 2018, accepted on 02 Jun 2018 and first published on 05 Jun 2018


Article type: Paper
DOI: 10.1039/C8TB00729B
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Black Phosphorus analogue Tin Sulfide Nanosheets: Synthesis and Application as Near-Infrared Photothermal Agents and Drug Delivery Platforms for Cancer Therapy

    Z. Xie, D. Wang, T. Fan, C. Xing, Z. Li, W. Tao, L. Liu, S. bao, D. Fan and H. Zhang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00729B

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