Jump to main content
Jump to site search


Controlled grafted poly(quartanized-4-vinylpyridine-co-acrylicacid) brushes allure bacteria for effective antimicrobial surfaces

Abstract

A copolymer poly(quarternized-4-vinylpyridine-co-acrylic acid) (P(Q4VP-co-AA)) brushes with an adsorbed aminoacid were grafted as a mean of attraction, contact-killing, and release of bacteria. The substrates silicon wafer (SW), glass, and PDMS were coated with 7-octenyltrichlorosilane (7OTS) followed by surface-initiated reversible addition-fragmentation transfer polymerization. The 7OTS allowed an easy control of the grafting density, and a maximum grafting density of 0.36 chains/nm2 was obtained. The L-glutamine (GA) was adsorbed to the P(Q4VP-co-AA) brushes, which ultimately desorb in a microbial environment created concentration gradient and causes the microbial movement toward the decorated surfaces. The P(Q4VP-co-AA) brushes at SW, glass, and PDMS substrate enable the contact-killing of 90±4, 93±5, and 92±3 % of Escherichia coli and 92±4, 93±3, and 91±4 % of Staphylococcus aureus from microbial conentration of 1×105 CFU/mL and 30 min exposure. After contact-killing these brushes completely release the microbes by dipping in NaCl (1 M) solution for 5 min. Thus, the ease in controlling the grafting density and substrate modification, capability of microbial attraction, high contact-killing efficiency, and self-sterilizing make P(Q4VP-co-AA)-GA brushes a useful material for the development of multi-functional antimicrobial substrates.

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Mar 2018, accepted on 09 May 2018 and first published on 14 May 2018


Article type: Paper
DOI: 10.1039/C8TB00702K
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    Controlled grafted poly(quartanized-4-vinylpyridine-co-acrylicacid) brushes allure bacteria for effective antimicrobial surfaces

    M. Khan, Z. Wu, S. Mao, S. N. A. Shah and J. Lin, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00702K

Search articles by author

Spotlight

Advertisements