Issue 22, 2018

Controlled grafted poly(quaternized-4-vinylpyridine-co-acrylic acid) brushes attract bacteria for effective antimicrobial surfaces

Abstract

Copolymer poly(quaternized-4-vinylpyridine-co-acrylic acid) (P(Q4VP-co-AA)) brushes with an adsorbed amino acid (L-glutamine (GA)) were grafted onto surfaces as a means of attracting, contact-killing, and releasing bacteria. The substrates, silicon wafer (SW), glass, and PDMS, were coated with 7-octenyltrichlorosilane (7OTS), and this was followed by surface-initiated reversible addition–fragmentation transfer (SI-RAFT) polymerization. The 7OTS allowed easy control of the grafting density, and a maximum grafting density of 0.36 chains per nm2 was obtained. The GA was initially adsorbed to the P(Q4VP-co-AA) brushes, and ultimately desorbed in a microbial environment-created concentration gradient, causing microbial movement toward the decorated surfaces. The P(Q4VP-co-AA) brushes at SW, glass, and PDMS substrates enabled the contact-killing of 90 ± 4, 93 ± 5, and 92 ± 3% of Escherichia coli and 92 ± 4, 93 ± 3, and 91 ± 4% of Staphylococcus aureus, respectively, from microbial concentrations of 1 × 105 CFU mL−1 and 30 min exposures. After contact-killing, these brushes completely released the microbes when they were dipped in NaCl (1 M) solution for 5 min. The ease of controlling the grafting density and substrate modification as well as the microbial attraction capability, high contact-killing efficiency, and self-sterilizing make P(Q4VP-co-AA)–GA brushes a useful material for the development of multi-functional antimicrobial substrates.

Graphical abstract: Controlled grafted poly(quaternized-4-vinylpyridine-co-acrylic acid) brushes attract bacteria for effective antimicrobial surfaces

Supplementary files

Article information

Article type
Paper
Submitted
15 Mar 2018
Accepted
09 May 2018
First published
14 May 2018

J. Mater. Chem. B, 2018,6, 3782-3791

Controlled grafted poly(quaternized-4-vinylpyridine-co-acrylic acid) brushes attract bacteria for effective antimicrobial surfaces

M. Khan, Z. Wu, S. Mao, S. N. A. Shah and J. Lin, J. Mater. Chem. B, 2018, 6, 3782 DOI: 10.1039/C8TB00702K

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