Jump to main content
Jump to site search

Issue 22, 2018
Previous Article Next Article

Polymeric chemosensor for the detection and quantification of chloride in human sweat. Application to the diagnosis of cystic fibrosis

Author affiliations

Abstract

We have developed a new extremely hydrophilic polymeric film suitable for the detection and quantification of chloride in human sweat directly on the skin. The film, or membrane, has chemically anchored 6-methoxyquinoline groups as chloride responsive fluorescent motifs. We have prepared the sensory material from a standard vinyl copolymer, by a convenient and easy solid-phase reaction. The sensory material has a water swelling percentage of 700%, facilitating an immediate detection of chloride, is reusable for at least 6 cycles and can be handled without care by unskilled persons. The initially high fluorescence of the material decreases in the presence of chloride, allowing the quantification of chloride concentration by using the colour definition of a digital picture or a fluorimeter. The suitability of the material to perform quantitative chloride analysis of human sweat by putting it in contact with the skin offers promise for its application in the sweat test used for the diagnosis of cystic fibrosis (CF).

Graphical abstract: Polymeric chemosensor for the detection and quantification of chloride in human sweat. Application to the diagnosis of cystic fibrosis

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Mar 2018, accepted on 23 Apr 2018 and first published on 30 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00682B
Citation: J. Mater. Chem. B, 2018,6, 3735-3741
  •   Request permissions

    Polymeric chemosensor for the detection and quantification of chloride in human sweat. Application to the diagnosis of cystic fibrosis

    S. Vallejos, E. Hernando, M. Trigo, F. C. García, M. García-Valverde, D. Iturbe, M. J. Cabero, R. Quesada and J. M. García, J. Mater. Chem. B, 2018, 6, 3735
    DOI: 10.1039/C8TB00682B

Search articles by author

Spotlight

Advertisements