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Dimeric BODIPY-loaded liposomes for dual hypoxia markers imaging and activatable photodynamic therapy against tumor

Abstract

This work reports a dimeric BODIPY (BDP)-loaded liposome with conjugation of anti-HIF antibody for dual hypoxia markers imaging and nitroreductase (NTR)-activatable photodynamic therapy (PDT) against hypoxic tumor. In this theranostic nanosystem (designated Ab-DiBDP NPs), the newly designed orthogonal BDP dimer has high singlet oxygen quantum yield, and the substitution of nitro group at meso-position lead to the NTR-controllable activation of phototoxicity and fluorescence. In vivo and in vitro experiments both demonstrate that the NTR-activatable PDT liposome can efficiently destroy cancer cells and prevent the damage to normal cells. More significantly, the fascinating advantage of the nanoprobe is the synergy between Cy 7-marked anti-HIF-1α antibody and the NTR-activatable DiBDP, which significantly improves the accuracy of tumor hypoxia imaging by simultaneous detection of NTR and HIF-1α. Therefore, this work presents a new paradigm for NTR-triggered PDT against cancer cells and provides a new avenue for precise tumor hypoxia diagnosis.

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Publication details

The article was received on 18 Mar 2018, accepted on 29 May 2018 and first published on 04 Jun 2018


Article type: Paper
DOI: 10.1039/C8TB00665B
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Dimeric BODIPY-loaded liposomes for dual hypoxia markers imaging and activatable photodynamic therapy against tumor

    H. Chen, Q. Bi, Y. Yao and N. Tan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00665B

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