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Construction and Synergistic Anticancer Efficacy of Magnetic Targeting Cabbage-like Fe3O4@MoS2@ZnO Drug Carriers

Abstract

A novel cabbage-like Fe3O4@MoS2@ZnO nanocomposite was successfully fabricated through a facile method. The as-prepared nanocomposites exhibited saturation magnetization of 45 emu/g, as well as possessed massive pore structure and large surface area, leading to high DOX loading capacity of 68.14 μg/mg, which could effectively deliver drug to tumor lesion sites under the action of magnetic targeting. The pH-dependent ZnO as a packaging component could block the pore to achieve controlled release of DOX under the stimulation tumor circumstance (pH 6.5) thereby reducing the side effects of DOX to normal cells and increasing the therapy effects to tumor cells. Moreover, the photothermal conversion efficiency contributed by the MoS2 under 808 nm NIR laser irradiation was utilized for realizing effective photothermal therapy (PTT) of cancer, which could integrate chemotherapy in a single system. So the resultant Fe3O4@MoS2@ZnO nanocomposites would have a hopeful prospect in biomedical applications by pH sensitivity, magnetic targeting and chemo-photothermal synergistic therapy.

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Publication details

The article was received on 06 Mar 2018, accepted on 14 May 2018 and first published on 15 May 2018


Article type: Paper
DOI: 10.1039/C8TB00608C
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Construction and Synergistic Anticancer Efficacy of Magnetic Targeting Cabbage-like Fe3O4@MoS2@ZnO Drug Carriers

    Y. Yang, B. Gong, Y. Yang, A. Xie, Y. Shen and M. Zhu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00608C

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