Jump to main content
Jump to site search


Gold nanoflowers-based traceable drug delivery system for intracellular SERS imaging-guided targeted chemo-phototherapy

Abstract

Accurate and effective drug delivery of tumor to significantly improve the curative effect with high drug delivery efficiency, low toxicity and side effects has become an urgent demand for anticancer therapy. In this paper, a novel traceable and targeted drug delivery nanosystem (i.e. AuNF-nanocarriers) with high drug encapsulation and pH-controlled release was prepared based on gold nanoflowers (AuNFs) for intracellular SERS imaging-guided efficient chemo-phototherapy. The SERS-active flower-like gold nanoparticles with large surface area were synthesized first and then modified with Raman and RGD molecules in sequence to prepare bright, traceable and targeted SERS tags of A549 human lung cancer cell. Further, the thiolated-PAA (PAA-SH) was synthesized and utilized for the first time to modify the SERS tags with a layer of negative charges for efficient pH-dependent load and release of the anti-cancer drug doxorubicin. Based on the A549 human lung cancer cell model, the availability of the proposed AuNF-nanocarriers for intracellular SERS imaging-guided efficient chemo-phototherapy was studied and the results indicate that the AuNFs-based drug delivery system had attractive characteristics of good stability, efficient and pH-controlled drug load and release, traceable and targeted delivery, as well as SERS imaging and chemo-phototherapy functions, which shows great potential to be a powerful SERS-imaging and theranostic candidate for precision nanomedicine that could achieve sensitive and accurate tumor detection and therapy.

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Mar 2018, accepted on 09 Apr 2018 and first published on 09 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00587G
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    Gold nanoflowers-based traceable drug delivery system for intracellular SERS imaging-guided targeted chemo-phototherapy

    C. Song, Y. Dou, L. Yuwen, Y. Sun, C. Dong, F. Li, Y. Yang and L. Wang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00587G

Search articles by author

Spotlight

Advertisements