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Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Abstract

Dendritic mesoporous silica nanoparticles (DMSNs) with a small diameter (~50 nm) and large pore size (>20 nm) have been synthesized at room temperature. It is shown that the choice of room temperature synthesis favours the formation of the large-pore and small-size DMSNs than conventional synthesis at higher temperature. Compared to mesoporous silica nanoparticles with a similar particle size but smaller mesopore size and DMSNs with a similar pore size but larger particle size, the DMSNs with both a small particle size and large pore size possess a higher in vitro mRNA transfection efficiency, indicating their potential as promising delivery vehicles for exogenous genetic molecules.

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Publication details

The article was received on 27 Feb 2018, accepted on 17 May 2018 and first published on 17 May 2018


Article type: Paper
DOI: 10.1039/C8TB00544C
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

    Y. Wang, H. Song, M. Yu, C. Xu, Y. Liu, J. Tang, Y. Yang and C. Yu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00544C

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