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Chemical modification of Halloysite nanotubes for controlled loading and release

Abstract

Clay minerals have been used for medical purposes from ancient times. Among them, halloysite nanotubes, an aluminosilicate of the kaolin group, is an emerging nanomaterial which possesses peculiar chemical characteristics. By means of suitable modifications, as supramolecular functionalizations or the covalent ones, it is possible to obtained novel nanomaterials with tunable properties for several applications. In this context the covalent grafting of suitable organic moieties on the exernal surface or in the HNT lumen has been exploited to improve the loading and release of several biological active molecules. The resulting hybrid nanomaterials have been applied as drug carrier and delivery systems, filler for hydrogels, in tissue regeneration and in gene delivery field. Furthermore the loading and release of specific molecules have been also investigated for environmental purposes. This review summarizes the main developments in the halloysite modifications in the last 20 years with a particular attention to the past two years.

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Publication details

The article was received on 27 Feb 2018, accepted on 13 Apr 2018 and first published on 16 Apr 2018


Article type: Review Article
DOI: 10.1039/C8TB00543E
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Chemical modification of Halloysite nanotubes for controlled loading and release

    S. Riela, M. Massaro, G. Cavallaro, C. G. Colletti, G. Lazzara, S. Milioto and R. Noto, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00543E

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