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Fabrication of Inherently Radiopaque BaSO4@BaAlg Microspheres by a One-step Electrospraying Method for Embolization

Abstract

A new one-step electrospraying method is developed to fabricate intrinsic X-ray imaging barium alginate microspheres loading with in situ synthesized BaSO4 particles (BaSO4@BaAlg microspheres). The electrospraying method is straightforward and environmentally friendly, involving only aqueous phase without any extra surfactant. It is also flexible. By varying the parameters of electrospraying, monodispersed BaSO4@BaAlg microspheres with a diameter range from 200 to 1800 μm are achieved to meet the requirements of precisely calibrated embolics and flexible clinical applications. BaSO4@BaAlg microspheres possess long-term X-ray imaging capability, which could show their own location and distribution precisely in real time during transcatheter arterial embolization operation, and be used for noninvasive examination after operation. The in vitro X-ray-visible stability test demonstrates that X-ray imaging capability of BaSO4@BaAlg microspheres is extremely stable. The fluctuation of radiodensity is within 7% of its original value during 52 days. Furthermore, digital radiography and computed tomography images of renal artery embolized with BaSO4@BaAlg microspheres confirm that the in vivo visibility under x-ray is kept constant for the embolization period of 3 weeks. Angiographic and histological studies on the embolized kidney verify that microspheres completely occlude the blood vessels of targeted kidney, including peripheral vessels.

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Publication details

The article was received on 27 Feb 2018, accepted on 09 Apr 2018 and first published on 09 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00542G
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Fabrication of Inherently Radiopaque BaSO4@BaAlg Microspheres by a One-step Electrospraying Method for Embolization

    Q. Du, L. Li, Y. Liu, J. Zeng, J. Li, C. Zheng, G. Zhou and X. Yang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00542G

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