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Versatile Multicolor Nanodiamond Probes for Intracellular Imaging and Targeted Labeling

Abstract

We report on a sizable production of fluorescent nanodiamonds (FNDs) containing a near infrared (NIR) color center – namely the silicon vacancy (SiV) defect, and their first demonstration inside cells for bio-imaging. We further demonstrate a concept of multi-color bio-imaging using FNDs to investigate intercellular processes using two types of FNDs. Due to their specific spectral properties, SiV FNDs can be distinguished from common nitrogen-vacancy (NV) FNDs and showed a distinct initial spreading throughout the cell interior. The reported results are the first demonstration of multi-color labeling with FNDs that especially interesting for in vivo bio-imaging due to stable fluorescence of FNDs.

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Publication details

The article was received on 23 Feb 2018, accepted on 06 Apr 2018 and first published on 06 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00508G
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Versatile Multicolor Nanodiamond Probes for Intracellular Imaging and Targeted Labeling

    K. Bray, L. Cheung, K. R. Hossain, I. Aharonovich, S. Valenzuela and O. Shimoni, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00508G

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