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Near-Infrared Light Triggered Photothermal Therapy and Enhanced Photodynamic Therapy with a Tumor-targeting Hydrogen Peroxide Shuttle

Abstract

Hypoxia, defined as inadequate oxygen supply at tissue level, is a common pathological condition in tumor microenvironment of certain solid tumors, leading to limited efficiency of oxygen-dependent photodynamic therapy (PDT). To overcome this problem, tumor-targeting oxygen self-carrying nanoparticles are developed for photothermal therapy (PTT) and enhanced PDT to completely eradicate solid tumors. Hydrogen peroxide (H2O2) is a strong oxidant that can release oxygen with the presence of a catalyst or being heated. The core-shell poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) are obtained by a double emulsion method: hydrophilic H2O2/poly(vinylpyrrolidone) complex as an oxygen source and hydrophobic IR780 as a PTT/PDT agent are encapsulated into the core and shell of the NPs respectively. Tumor binding molecule, folic acid, is conjugated onto the surface of obtained PLGA NPs to enabling efficient cell uptake and tumor targeting. Once PLGA-FA/IR780-H2O2 NPs are ingested by HepG2 cells, it can induce photothermal effect and reactive oxygen species (ROS) release to kill cancer cells under an 808 nm laser irradiation. The encapsulated H2O2 can supply additional oxygen and in turn significantly enhance the PDT effect. This innovative nanoplatform has exhibited excellent antitumor efficiency, verified vividly by in vitro and in vivo assay, and may serve as a versatile platform for future cancer therapy.

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Publication details

The article was received on 20 Feb 2018, accepted on 11 Apr 2018 and first published on 13 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00476E
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Near-Infrared Light Triggered Photothermal Therapy and Enhanced Photodynamic Therapy with a Tumor-targeting Hydrogen Peroxide Shuttle

    B. Wang, W. Lin, Z. Mao and C. Gao, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00476E

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