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A Theranostic System Based on NaY(Mn)F4:Yb/Er Upconversion Nanoparticles with multi-drug resistance (MDR) reversing ability

Abstract

For synchronous theranostic systems, two focuses are highly concerned: excellent in vivo imaging and multi-drug resistance (MDR) reversing ability for chemotherapy. Upconversion nanoparticles (UCNPs) exhibiting bright red emission in the “optical window in biological tissue (600-1100 nm)” could be a very candidate, while there are only a few reports on UCNP-based conjugates with their MDR reversal ability explored for chemtherapy. Herein, we report our synthetic optimization for bright red emitter NaY(Mn)F4:Yb/Er UCNPs (UN), together with the fabrication of an innovative theranostic system (D-UNT) via binding an antitumor drug (DOX) and a MDR reversal agent (TPGS) to our UCNPs. Our in vitro study demonstrated that the D-UNT was uptaken into drug-resistant MCF-7/ADR cells via caveolin dependent endocytosis, and overcame P-gp mediated efflux. The cytotoxicity was significantly promoted to be much higher than that of free DOX. Accordingly, our D-UNT illustrates enhanced reversal ability for chemtherapy. Our in vivo study further supported that the D-UNT had excellent therapeutic efficacy against MDR tumors with minimial organ toxicity detected. In vivo deep-tissue imaging showed that the D-UNT diagnosed accurately MDR tumors at 1.5 cm depth with high-contrast luminescent signals. Thus, the D-UNT is an effective theranostic system for the diagnosis and theraptics of MDR tumors. The present work opens new pathways to engineer powerful theranostic agents to simultaneously target, image and kill deep-tissue MDR tumor cells.

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Publication details

The article was received on 10 Feb 2018, accepted on 02 May 2018 and first published on 05 May 2018


Article type: Paper
DOI: 10.1039/C8TB00416A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    A Theranostic System Based on NaY(Mn)F4:Yb/Er Upconversion Nanoparticles with multi-drug resistance (MDR) reversing ability

    X. Chen, J. Sun, H. Zhao, K. Yang, Y. Zhu, H. Luo, K. Yu, H. Fan and X. Zhang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00416A

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