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A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

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Abstract

Here, we propose a highly sensitive and rapid bio-sensor for the detection of bio-markers for stroke and cancer-related diseases, based on the utilization of the adsorption properties of ruthenium carbonyl (Ru–CO) clusters on monolayer graphene (MG). A fast rate of decarbonylation of Ru–CO to form ruthenium oxide nanoparticles (RuO2 NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO2 NPs. A concentration as low as 17 ng mL−1 of MMP-2 was detected in a simulated clinical serum sample. This effective bio-sensor has the potential to revolutionize the biomedical field in the early detection and possible prevention of stroke and cancer diagnosis.

Graphical abstract: A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

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Publication details

The article was received on 09 Feb 2018, accepted on 15 Mar 2018 and first published on 15 Mar 2018


Article type: Communication
DOI: 10.1039/C8TB00404H
Citation: J. Mater. Chem. B, 2018, Advance Article
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    A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

    D. Lin, C. Tseng, Q. F. Lim, M. J. Tan and K. V. Kong, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C8TB00404H

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