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Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular imaging and real-time two-photon lung vasculature imaging

Abstract

Fluorescent organic nanoparticles based on small molecules have emerged as an attractive class of fluorescent agents for bioimaging in recent years. Herein, we report an orange light-emitting BTPEBD based organic nanoparticles (BTPEBD NPs) with a large Stokes shift (> 135 nm), ultrahigh quantum yield (> 90% in water) and aggregation-induced emission characteristics. Single nanoparticle analysis studied by wide field microscopy imaging further proves that BTPEBD NPs exhibit high brightness and good photostability. Both in-vitro and in-vivo experiments reveal that BTPEBD NPs are promising fluorescent agents for cellular imaging and real-time two-photon lung vasculature imaging.

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Publication details

The article was received on 08 Feb 2018, accepted on 03 Apr 2018 and first published on 11 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00386F
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular imaging and real-time two-photon lung vasculature imaging

    B. Liu, M. Evrard, X. Cai, G. Feng, N. Tomczak, L. G. Ng and J. Liu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00386F

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