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Simultaneous Hydrothermal Bioactivation with Nano-topographic Modulation of Porous Titanium Alloy towards Enhanced Osteogenic and Antimicrobial Responses

Abstract

Post-implantation failure associated with insufficient host tissue integration at bone-implant interface and aseptic loosening is a major concern in orthopaedics as well as dentistry. To overcome failure in early stages of implantation, prosthetics design combining the mechanisms of porosity guided bone ingrowth along with topographic manipulation of osteogenic cells over bacterial colonization would be an ideal choice, although achieving such goal is highly challenging. In this study, facile rapid hydrothermal synthesis of nanostructures with simultaneous deposition of hydroxyapatite on titanium alloy surface was demonstrated by using aqueous sodium tripolyphosphate and calcium hydroxide mixture. Nanostructures with wire-like morphology exhibited significantly higher osteogenic related genes expression (COL I, OPN, OCN) through differentiation of adipose derived mesenchymal stem cells as well as bactericidal response against S. aureus and E. coli as compared to the other nanotopographic features. The same also exhibited elongated cell morphology with the highest expression of paxillin towards cell boundaries as compared to the polished surface with flattened cell morphology and localized expression of paxillin around the nucleus. Implantation of treated porous Ti6Al4V samples representing multiscalar hierarchy with wire-like nanostructures accelerated osteochondral healing in rabbit without any major sign of infection. Also, significantly higher bone formation was observed within the defects implanted with treated porous Ti6Al4V (44.0%) as compared to that of untreated porous samples (36.9%) as well as empty defects (19.6%).

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Publication details

The article was received on 07 Feb 2018, accepted on 27 Mar 2018 and first published on 31 Mar 2018


Article type: Paper
DOI: 10.1039/C8TB00382C
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Simultaneous Hydrothermal Bioactivation with Nano-topographic Modulation of Porous Titanium Alloy towards Enhanced Osteogenic and Antimicrobial Responses

    K. Kapat, P. P. Maity, A. P. Rameshbabu, P. K. Srivas, P. Majumdar and S. Dhara, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00382C

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