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Issue 16, 2018
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NH2-Ni-MOF electrocatalysts with tunable size/morphology for ultrasensitive C-reactive protein detection via an aptamer binding induced DNA walker–antibody sandwich assay

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Abstract

Here we report a general approach for synthesizing size/morphology-controlled NH2-Ni-MOFs by optimizing the solvent composition in the reaction system, and their correlating catalytic performances are clearly explored for the first time. Interestingly, the electrocatalytic performance was found to increase 2.7 fold when the particle size is reduced from 1.5 μm for NH2-Ni-MOF(a) to 300 nm for NH2-Ni-MOF(c). Subsequently, this work exhibits an example of a high-performance NH2-Ni-MOF(c) electrocatalyst for application in constructing an electrochemical aptasensor to achieve sensitive C-reactive protein (CRP) detection based on an aptamer binding induced DNA walker–antibody sandwich assay. The proposed aptasensor shows a wide linear range from 0.1 pg mL−1 to 100 ng mL−1 with a low detection limit of 0.029 pg mL−1. The work presented here can thus offer an atypical approach to size- and morphology-controlled MOFs in electrocatalysis and biosensing.

Graphical abstract: NH2-Ni-MOF electrocatalysts with tunable size/morphology for ultrasensitive C-reactive protein detection via an aptamer binding induced DNA walker–antibody sandwich assay

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Publication details

The article was received on 06 Feb 2018, accepted on 23 Mar 2018 and first published on 24 Mar 2018


Article type: Paper
DOI: 10.1039/C8TB00373D
Citation: J. Mater. Chem. B, 2018,6, 2426-2431
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    NH2-Ni-MOF electrocatalysts with tunable size/morphology for ultrasensitive C-reactive protein detection via an aptamer binding induced DNA walker–antibody sandwich assay

    Z. Wang, P. Dong, Z. Sun, C. Sun, H. Bu, J. Han, S. Chen and G. Xie, J. Mater. Chem. B, 2018, 6, 2426
    DOI: 10.1039/C8TB00373D

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