Jump to main content
Jump to site search

Issue 14, 2018
Previous Article Next Article

Marriage of artificial catalase and black phosphorus nanosheets for reinforced photodynamic antitumor therapy

Author affiliations

Abstract

Two dimensional (2D) semiconducting nanomaterials have shown great potential for antitumor therapy. However, their clinical applications are seriously hampered by the tumour microenvironments. Bearing this in mind, we propose to improve the performance of 2D semiconducting nanomaterials using artificial catalase. In this work, we decorate black phosphorus (BP) nanosheets with Pt nanoparticles (NPs) through an in situ growth strategy. Pt NPs as artificial catalases can efficiently decompose the accumulated H2O2 in tumours to relieve tumour hypoxia, and thereafter improve the photodynamic antitumor activity of BP nanosheets. This work paves a new avenue for the functionalization of 2D semiconducting nanomaterials, which will promote the development of 2D semiconductor based nanodrugs.

Graphical abstract: Marriage of artificial catalase and black phosphorus nanosheets for reinforced photodynamic antitumor therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Feb 2018, accepted on 07 Mar 2018 and first published on 09 Mar 2018


Article type: Paper
DOI: 10.1039/C8TB00371H
Citation: J. Mater. Chem. B, 2018,6, 2057-2064
  •   Request permissions

    Marriage of artificial catalase and black phosphorus nanosheets for reinforced photodynamic antitumor therapy

    J. Ouyang, Y. Deng, W. Chen, Q. Xu, L. Wang, Z. Liu, F. Tang, L. Deng and Y. Liu, J. Mater. Chem. B, 2018, 6, 2057
    DOI: 10.1039/C8TB00371H

Search articles by author

Spotlight

Advertisements