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An ATP/ATPase responsive supramolecular fluorescent hydrogel constructed via electrostatic interactions between poly(sodium p-styrenesulfonate) and a tetraphenylethene derivative

Abstract

By electrostatic interactions between poly(sodium p-styrenesulfonate) 1 and tetraphenylethene (TPE) derivative 2 containing two quaternary ammonium cations, a novel bioresponsive supramolecular fluorescent hydrogel 3 was constructed. This self-assembly process led to the aggregation of TPE, a typical chromophore with aggregation-induced emission (AIE) property, thereby endowing this hydrogel with the AIE fluorescence property. Moreover, this supramolecular fluorescent hydrogel was responsive to biomolecues. When ATP was added to this system, it interacted with 2 stronger than 1. Correspondingly, the network structure of the hydrogel was destroyed and the aggregation extent of 2 was decreased, which induced the transition from gel to sol and decreased the fluorescence intensity of the hydrogel at the same time. Subsequently, after phosphatase ATPase was added into the solution, ATP was decomposed and the electrostatic interactions between 1 and 2 were rebuilt, transforming sol into gel and recovering the fluorescence intensity of the hydrogel. Therefore, the fluorescent supramolecular hydrogel 3 was bioresponsive. Simultaneously, this fluorescent supramolecular hydrogel 3 could cross over cell membrane and enter cytoplasm, which could be applied in the cell imaging and could stain the cell membrane with blue fluorescence.

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Publication details

The article was received on 06 Feb 2018, accepted on 09 Apr 2018 and first published on 10 Apr 2018


Article type: Communication
DOI: 10.1039/C8TB00366A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    An ATP/ATPase responsive supramolecular fluorescent hydrogel constructed via electrostatic interactions between poly(sodium p-styrenesulfonate) and a tetraphenylethene derivative

    H. Wang, X. Ji, Y. Li, Z. li, G. Tang and F. Huang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00366A

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