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Issue 18, 2018
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Exosomes separated based on the “STOP” criteria for tumor-targeted drug delivery

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Abstract

Exosomes, a class of natural nanoparticles, have recently been used for drug delivery. To move from bench to bedside, exosomes should meet the “STOP” criteria: (1) high Safety; (2) good Targeting ability; (3) rapid Obtainment; and (4) high Purity. To the best of our knowledge, however, no studies on exosomes that can satisfy all the abovementioned criteria have been reported to date. In this study, an optimized superparamagnetic nanoparticle cluster (SMNC)-based method was used to easily achieve the abovementioned objective. Multiple superparamagnetic nanoparticles (SPMNs) labeled by holo-transferrin with PEG spacers anchor onto an exosome to form an upgraded exosome-based superparamagnetic nanoparticle cluster (denoted SMNC-EXO-PLUS). SMNC-EXO-PLUSs separated exosomes from healthy animal blood to ensure high safety, and their formation based on the specific binding of SPMNs to exosomes endowed exosomes with high purity. In addition, SMNC-EXO-PLUSs possessed strong magnetic response, realizing their rapid obtainment and good targeting ability. The results demonstrated that the cell viability was maintained as high as 88% in a 1000 μg mL−1 SMNC-EXO-PLUS solution, and the time interval from the extraction of blood to the acquisition of purified exosomes could be reduced to 3.5 h. Furthermore, the effects of in vivo tumor inhibition of drug-loaded SMNC-EXO-PLUSs (denoted as D-SMNC-EXO-PLUSs) were pronounced. Based on the “STOP” criteria, we exploited a new exosome-related drug delivery vehicle, dramatically promoting the clinical translation of exosomes.

Graphical abstract: Exosomes separated based on the “STOP” criteria for tumor-targeted drug delivery

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Publication details

The article was received on 05 Feb 2018, accepted on 02 Apr 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00355F
Citation: J. Mater. Chem. B, 2018,6, 2758-2768
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    Exosomes separated based on the “STOP” criteria for tumor-targeted drug delivery

    H. Qi, L. Yang, X. Li, Q. Zhan, D. Han, J. Zhao, X. Hou and X. Yuan, J. Mater. Chem. B, 2018, 6, 2758
    DOI: 10.1039/C8TB00355F

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