Jump to main content
Jump to site search


A Zeolitic Imidazolate Framework-8 Based Indocyanine Green Theranostic Agent for Infrared Fluorescence Imaging and Photothermal Therapy

Abstract

Indocyanine green (ICG), as the only near-infrared (NIR) dye approved by United States Food and Drug Administration (FDA), is highly desirable but still remains some bottlenecks in clinic application, such as poor photostability, poor thermal stability and lack of target specificity. To solve these problems, a zeolitic imidazolate framework-8 (ZIF-8) based ICG theranostic agent was constructed by one-pot synthesis for fluorescence imaging and photothermal therapy (PTT). As-synthesized ICG@ZIF-8 nanoparticles (NPs) displayed ultrahigh loading capacity, superior photothermal stability, good anti-photobleaching ability, good biocompatibility, efficient cellular uptake and favourable photothermal killing capacity for SMMC-7721 cells. Importantly, in vivo experiments indicated that ICG@ZIF-8 NPs showed an accurate and sensitive detection of tumor by fluorescence molecular imaging. Meanwhile, ICG@ZIF-8 NPs efficiently induced local ablation effect for PTT under a single NIR laser irradiation. The tumor was completely suppressed, no tumor recurrence and treatments-induced toxicity were observed. The described particles have the potential to act as a promising platform for cancer theranostic nanomedicine.

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Feb 2018, accepted on 11 May 2018 and first published on 13 May 2018


Article type: Paper
DOI: 10.1039/C8TB00351C
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    A Zeolitic Imidazolate Framework-8 Based Indocyanine Green Theranostic Agent for Infrared Fluorescence Imaging and Photothermal Therapy

    T. Wang, S. Li, Z. zou, L. Hai, X. Yang, X. Jia, A. Zhang, D. He, X. He and K. Wang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00351C

Search articles by author

Spotlight

Advertisements